Endotoxin adsorbent
AssigneeNagase Chemtex Corporation
InventorsDaisuke Nakamura, Yuki Maeda
Life of this patent
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Abstract
An endotoxin adsorbent comprising a crystalline cellulose having a nitrogen atom-containing cationic group can sufficiently remove endotoxin from a material containing endotoxin to be removed and containing a substance having a cationic group and can efficiently remove endotoxin also from a highly viscous material. The nitrogen atom-containing cationic group may be typically a functional group derived from a polyvalent amine and/or a quaternary ammonium salt. The crystalline cellulose having a nitrogen atom-containing cationic group may comprise the nitrogen atom-containing cationic group at a content of 0.05 to 3 meq/dry·g in terms of anion exchange capacity.
Claims13
An endotoxin adsorbent consisting essentially of a crystalline cellulose having a nitrogen atom-containing cationic group, wherein the nitrogen atom-containing cationic group is introduced into hydroxy group(s) of the crystalline cellulose directly or through at least one activating agent selected from the group consisting of chloromethyloxirane, diglycidyl ether, epibromohydrin, ethylene glycol diglycidyl ether, p-toluenesulfonyl chloride, 2-fluoro-1-methylpyridinium, chloroacetyl chloride, hexamethylene diisocyanate, m-xylene diisocyanate, and toluene-2,4-diisocyanate.
Dependencies are inferred from the claim text.