Diffusion and infusion resistant implantable devices for reducing pulsatile pressure
AssigneeAria CV, Inc.
InventorsKarl Vollmers, Lynn Zwiers, John Gainor, John Scandurra
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Abstract
Diffusion and infusion resistant implantable devices and methods for reducing pulsatile pressure are provided. The implantable device includes a balloon implantable within a blood vessel of a patient, e.g., the pulmonary artery. The balloon is injected with a fluid mixture comprising a constituent fluid(s) and a diffusion-resistant gas to provide optimal balloon volume and limit fluid diffusion throughout multiple cardiac cycles. The fluid mixture may be pressurized such that the balloon is transitionable between an expanded state and a collapsed state responsive to pressure fluctuations in the blood vessel.
Claims30
A system for reducing pulsatile pressure, the system comprising:
- a fluid mixture;
- and
- a balloon configured to be implanted in a blood vessel and to hold the fluid mixture pressurized such that the balloon transitions between an expanded state and a collapsed state responsive to pressure fluctuations in the blood vessel, the fluid mixture comprising one or more constituent fluids and a diffusion-resistant fluid configured to maintain a desired volume and pressure within the balloon throughout multiple cardiac cycles, wherein each of the constituent fluids of the fluid mixture is pressurized within the balloon to match their respective partial pressure in the blood surrounding the balloon within the blood vessel to reduce permeation of fluids across the balloon throughout multiple cardiac cycles.
A system comprising:
- a balloon configured to be implanted within a blood vessel;
- and
- a fluid mixture comprising one or more constituent fluids mixed with sulfur hexafluoride, wherein the sulfur hexafluoride makes up between 8-25% of the fluid mixture, and wherein each of the one or more constituent fluids is pressurized within the balloon to match their respective partial pressure in the blood surrounding the balloon within the blood vessel to reduce permeation of fluids across the balloon throughout multiple cardiac cycles.
A method for introducing fluids into an implantable system, the method comprising:
- implanting a balloon within a blood vessel of a patient;
- introducing a diffusion-resistant fluid into the balloon;
- introducing one or more constituent fluids into the balloon in an amount to reach a known state, the diffusion-resistant fluid different than the one or more constituent fluids;
- and
- introducing an additional amount of the one or more constituent fluids into the balloon,
- wherein each of the one or more constituent fluids is pressurized within the balloon to match their respective partial pressure in the blood surrounding the balloon within the blood vessel to reduce permeation of fluids across the balloon throughout multiple cardiac cycles, and
- wherein the diffusion-resistant fluid and the one or more constituent fluids within the balloon are pressurized such that the balloon is transitionable between an expanded state and a collapsed state responsive to pressure fluctuations in the blood vessel.
Dependencies are inferred from the claim text.