Systems and methods for compensating long term sensitivity drift of electrochemical gas sensors exposed to nitric oxide

A gas delivery system comprising:

• a system controller including a memory having stored thereon a calibration schedule for performing a plurality of baseline calibrations and a calibration line correlating expected sensor output values from a nitric oxide sensor to nitric oxide gas concentration;
• a breathing circuit configured to deliver nitric oxide to a patient;
• and
• the nitric oxide sensor configured to continuously measure a concentration of nitric oxide in the breathing circuit and communicate with the system controller;
• wherein the system controller is configured to deliver nitric oxide to the patient according to an input set dosage;
• wherein the system controller is configured to identify according to the calibration schedule in the memory when the plurality of baseline calibrations is intended to be performed, accounting for the input set dosage;
• wherein the system controller is further configured to schedule a time for executing the plurality of baseline calibrations of the nitric oxide sensor according to the calibration schedule;
• wherein the system controller changes the calibration schedule upon a change in the input set dosage;
• wherein the calibration schedule is based on the input set dosage;
• wherein the system controller is configured to adjust the measurements of the nitric oxide sensor according to the calibration line;
• wherein during the plurality of baseline calibrations the nitric oxide sensor measures an output value indicative of a zero concentration of nitric oxide while only being exposed to a gas having a zero concentration of nitric oxide;
• and
• wherein the system controller is configured to offset the calibration line by the absolute value of the output value indicative of a zero concentration of nitric oxide.

A gas delivery system comprising:

• a system controller including a memory having stored thereon a calibration schedule for performing a plurality of baseline calibrations and a calibration line correlating expected sensor output values from at least one four terminal electrochemical nitric oxide gas sensor to nitric oxide gas concentration;
• a breathing circuit configured to deliver nitric oxide gas to a patient;
• and
• at least one four terminal electrochemical nitric oxide gas sensor configured to continuously measure a concentration of nitric oxide in the breathing circuit and communicate with the system controller;
• wherein the system controller is configured to deliver the nitric oxide gas to the patient according to an input set dosage;
• wherein the system controller is configured to identify according to the calibration schedule in the memory when the plurality of baseline calibrations is intended to be performed accounting for the input set dosage, wherein the plurality of the baseline calibration occurs sooner based upon a larger change in set dosage;
• wherein the system controller is further configured to schedule a time for executing the plurality of the baseline calibration of the at least one four terminal electrochemical nitric oxide gas sensor according to the calibration schedule;
• wherein the system controller changes the calibration schedule upon a change in the set dosage;
• wherein the calibration schedule is based on the set dosage;
• wherein the system controller is configured to adjust the measurements of the at least one four terminal electrochemical nitric oxide gas sensor according to the calibration line;
• wherein during the plurality of baseline calibrations the sensor measures an output value indicative of a zero concentration of nitric oxide while only being exposed to a gas having a zero concentration of nitric oxide;
• and
• wherein the system controller is configured to offset the calibration line by the absolute value of the output value indicative of a zero concentration of nitric oxide.