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US 11,141,526 B2Granted
Compositions, devices and kits for selective internal radiation therapy
AssigneeBetaGlue Technologies S.p.A
InventorsAntonino Amato, Giovanni Paganelli
Life of this patent
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Abstract
Systems, kits and methods for preparing an injection system and/or treating target lesions with a selective internal radiation therapy which includes a double-barrel syringe loaded with a two-component tissue glue and radioisotope loaded microspheres. The microspheres are loaded into the syringe based on the size of the target location and are administered with a needle or dual-lumen catheter. Dosing regimens for treating breast cancer lesions or surgical beds up to 130 mm in diameter and hepatocellular carcinoma lesions up to 50 mm are included.
Claims11
A method of treating breast cancer, comprising:
- determining an average tumor size of a breast cancer lesion;
- selecting a 90Y syringe activity level and a 90Y treatment activity level using the average tumor size, wherein the 90Y treatment activity level is:
- a. 15 MBq to 20 MBq for the average tumor size corresponding to a radius in the range of 20 mm to 24 mm;
- b. 20 MBq to 25 MBq for the average tumor size corresponding to a radius in the range of 25 mm to 29 mm;
- c. 25 MBq to 35 MBq for the average tumor size corresponding to a radius in the range of 30 mm to 34 mm;
- d. 40 MBq to 50 MBq for the average tumor size corresponding to a radius in the range of 35 mm to 39 mm;
- e. 55 MBq to 65 MBq for the average tumor size corresponding to a radius in the range of 40 mm to 44 mm;
- f. 75 MBq to 85 MBq for the average tumor size corresponding to a radius in the range of 45 mm to 49 mm;
- g. 90 MBq to 100 MBq for the average tumor size corresponding to a radius in the range of 50 mm to 54 mm;
- loading a dual chamber syringe with the selected 90Y syringe activity level, wherein the dual chamber syringe comprises a first chamber pre-loaded with bovine serum albumin and a second chamber pre-loaded with glutaraldehyde;
- and
- injecting the selected 90Y treatment activity level at a treatment site of the breast cancer lesion using the dual chamber syringe.
9 more elements
Dependencies are inferred from the claim text.