Compositions for cell-based three dimensional printing
AssigneeRevotek Co., Ltd
InventorsYujian James Kang, Xiao Zuo
Life of this patent
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Abstract
A bio-ink composition comprises a plurality of bio-block, in which the bio-blocks can serve as basic building blocks in cell-based bioprinting. The bio-blocks, pharmaceutical compositions comprising the bio-blocks, methods of preparing artificial tissues, tissue progenitors, or multi-dimensional constructs, and methods of preparing the bio-blocks are also provided. The bio-blocks, and the multi-dimensional constructs, artificial tissues, and tissue progenitors comprising the bio-blocks or prepared by the methods described herein are useful for tissue engineering, in vitro research, stem cell differentiation, in vivo research, drug screening, drug discovery, tissue regeneration, and regenerative medicine.
Claims19
A bio-block, which is a basic building block for bio-printing using a three-dimensional (3D) bio-printer, comprising:
- a) a core comprising a biodegradable core material and 25-5000 cells, and b) a shell comprising a biodegradable shell material;
- wherein the bio-block has sufficient mechanical strength so that three-dimensional deposition by a 3D bio-printer can be achieved;
- wherein the bio-block has a hardness of 0.01-0.4 GPa and a modulus of elasticity of 0.01-100 MPa.
Dependencies are inferred from the claim text.