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US 11,141,509 B2Granted
Method for loading at least two powder substances into recesses provided at a stent surface
AssigneeCID, Inc.
InventorsIlaria Zambaldi, Franco Vallana, Matteo Antoniotti, Andrea Grignani
Life of this patent
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Abstract
In an embodiment, a method for loading a powder substance (10) into recesses (200) provided at a stent (S) surface, the method comprises: applying compression (100) to the powder substance (10) to thereby form tablets insertable into said recesses (200), inserting the tablets into the recesses (200) of the stent (S).
Claims13
A method for loading at least two powder substances into recesses (200) provided at a stent (S) surface, the method comprising:
- applying compression (100) to at least one powder substance (10) to thereby form tablets insertable into said recesses (200),
- loading at least one additional substance (20) into said recesses (200), by partially filling said recesses (200) with said at least one additional substance, wherein said at least one additional substance (20) includes a powder substance and
- inserting said tablets of said at least one substance (10) into said recesses partially filled with said at least one additional substance (20), wherein
- said at least one substance (10) includes an active principle with anti-inflammatory activity mixed with at least one or more first excipients selected from linear or branched saturated fatty acids,
- said at least one additional substance (20) includes an active principle with anti-proliferative activity mixed with at least one or more second excipients selected from linear or branched saturated fatty acids,
- wherein said at least one first excipient or mixture of first excipients has a melting temperature lower than the melting temperature of said at least one second excipient or mixture of second excipients, and
- wherein the melting temperature of said at least one first excipient or mixture of first excipients is between 50° C. and 65° C. and the melting temperature of said at least one second excipient or mixture of second excipients is between 68° C. and 80° C., so that upon implantation of said stent to a patient said at least one substance (10) is released in less than about 5 days after implantation and said at least one additional substance (20) is released between 1 and 4 months after implantation.
4 more elements
A method for loading a powder substance into recesses (200) provided at a stent (S) surface, the method comprising:
- i) providing a tablet insertable into said recesses (200) comprising at least one powder substance (10), wherein said tablet has been formed by applying compression (100) to said at least one powder substance (10);
- ii) loading at least one additional substance (20) into said recesses (200), by partially filling said recesses (200) with said at least one additional substance, wherein said at least one additional substance (20) includes a powder substance;
- iii) subjecting the stent obtained in step ii) to a heat treatment at a temperature T1 for stabilizing the at least one additional substance (20) loaded on the stent;
- iv) inserting said tablets of said at least one substance (10) into said recesses partially filled with said at least one additional substance (20);
- v) subjecting the stent obtained in step iv) to a heat treatment at a temperature T2 whereby said at least one substance (10) forms a closing lid of said recesses;
- wherein
- aid at least one substance (10) includes an active principle with anti-inflammatory activity mixed with at least one or more first excipients selected from linear or branched saturated fatty acids comprising a number of carbon atoms between 4 and 18,
- said at least one additional substance (20) includes an active principle with anti-proliferative activity mixed with at least one or more second excipients selected from linear or branched saturated fatty acids comprising a number of carbon atoms between 16 and 34,
- wherein said at least one first excipient or mixture of first excipients has a melting temperature lower than the melting temperature of said at least one second excipient or mixture of second excipients,
- wherein the temperature T1 is greater than the temperature T2, and
- wherein said temperature T1 is between 68° C. and 80° C. and said temperature T2 is between 50° C. and 65° C.
8 more elements
Dependencies are inferred from the claim text.