Macro-encapsulated therapeutic cells, devices, and methods of using the same
AssigneeSeraxis, Inc.
InventorWilliam L Rust
Life of this patent
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Abstract
Described are macro-capsules, barriers, and devices that can be used to prepare therapeutic cell implants, methods of encapsulating therapeutic cells, and methods of using the encapsulated cells in the treatment of disease.
Claims34
A device comprising a piece of surgical mesh and a plurality of macro-capsules encompassing a plurality of therapeutic cells, the macro-capsule comprising a first barrier and a second barrier encompassing the first barrier, wherein the first barrier comprises:
- (a) cellulose sulfate and glucomannan or glucomannan sulfate;
- or
- (b) sodium alginate,
- wherein the macro-capsule has a cylindrical shape and a diameter of at least 1.5 mm, and
- wherein the macro-capsules are attached to the piece of surgical mesh.
A composition comprising a cylindrical macro-capsule encompassing a plurality of insulin-producing therapeutic cells, the macro-capsule comprising a first barrier and a second barrier, the first barrier comprising:
- (a) cellulose sulfate and glucomannan or glucomannan sulfate;
- or
- (b) sodium alginate;
- wherein the macro-capsule is attached to a piece of surgical mesh to which at least one other macro-capsule is also attached, and wherein the diameter of the macro-capsule is at least 1.5 mm.
A composition comprising a plurality of macro-capsules encompassing a plurality of insulin-producing therapeutic cells, each macro-capsule comprising at least a first barrier and a second barrier, wherein the first barrier is encompassed within the second barrier, wherein each macro-capsule has a diameter of at least 1.5 mm, and wherein each macro-capsule in the plurality of macro-capsules is attached to a piece of surgical mesh.
A composition comprising a macro-capsule encompassing at least 50,000 insulin-producing therapeutic cells per cm, the macro-capsule comprising a cylindrical shape, a length of at least 11 cm, and a diameter of at least 1.5 mm, wherein the macro-capsule is attached to a piece of surgical mesh to which at least one other macro-capsule is also attached, wherein the macro-capsule comprises at least a first barrier and a second barrier, wherein the first barrier is encompassed within the second barrier, and wherein the first barrier comprises:
- (a) cellulose sulfate and glucomannan or glucomannan sulfate;
- or (b) sodium alginate.
Dependencies are inferred from the claim text.