Use of berberine or derivative thereof in preparing myocardial perfusion imaging agent
AssigneeWest China Hospital, Sichuan University
InventorsChengzhong Fan, Xiaoai Wu, Meng Liang, Xiaoli Mei, Tong Zhang, Rang Wang, Haotian Chen
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Abstract
Berberine or its derivatives are used in the preparation of myocardial perfusion imaging agents It has been verified using in vitro investigations, in vivo biodistribution, and small animal PET dynamic imaging, etc., that 18F-labeled berberine derivatives can specifically accumulate in cardiomyocytes or heart tissues, and has good distribution properties of targetting heart muscle in living animals, together with high contrast values of heart v.s. peripheral tissue (liver, lung, blood, muscle, bone, etc.).
Claims4
A method for myocardial perfusion imaging, comprising:
- intravenously injecting a compound comprising a berberine derivative to a subject in need thereof;
- and
- carrying out myocardial perfusion imaging of the subject,
- wherein the berberine derivative is radiolabeled with 18F and has a structural formula of
- wherein n=2 or 3.
A method for diagnosing a coronary heart disease, comprising:
- intravenously injecting a compound comprising a berberine derivative to a subject in need thereof;
- and
- carrying out myocardial perfusion imaging of the subject, wherein the berberine derivative is radiolabeled with 18F and has a structural formula of
- wherein n=2 or 3.
Dependencies are inferred from the claim text.