Development of neurokinin-1 receptor-binding agent delivery conjugates
AssigneePurdue Research Foundation
InventorsAnanda Kumar Kanduluru, Philip S. Low
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Abstract
Neurokinin-1 (NK-1) receptor-binding agent delivery conjugates, compositions comprising NK-1 receptor-binding agent delivery conjugates, and methods for making and administering NK-1 receptor-binding agent delivery conjugates are provided. A conjugate may include an NK-1 receptor-binding moiety, a linker group containing at least one linker selected from the group of a releasable linker and a spacer linker, and an active agent linked to the linker group. The active agent may be selected from the group of fluorophore-containing compounds, radionuclide-containing compounds, and therapeutic agents for treatment of tumor cells characterized by over-expression of the NK-1 receptor.
Claims5
A neurokinin-1 (NK-1) receptor-binding agent delivery conjugate, comprising:
- an NK-1 receptor-binding moiety;
- a linker group selected from the group consisting of:
- an active agent comprising fluorescein,
- wherein the NK-1 receptor-binding moiety and the active agent are each bound to the linker group.
Dependencies are inferred from the claim text.