Anticancer combinations
AssigneeCity of Hope
InventorsDon J. Diamond, Edwin Manuel
Life of this patent
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Abstract
Provided herein, inter alia, are compositions and kits comprising a bacterial cell and a tumor penetrating agent. Also provided are methods of treating cancer in a subject including the step of administering to the subject an effective amount of a bacterial cell and a tumor penetrating agent. Provided are methods of stimulating an immune system in a subject. The methods include administering to the subject an effective amount of a bacterial cell and a tumor penetrating agent. Also provided are methods of enhancing delivery of an anti-cancer agent to a tumor cell including the step of contacting the tumor cell with a bacterial cell, a tumor penetrating agent and an anti-cancer agent.
Claims14
A method of treating cancer in a subject comprising administering to the subject a combined effective amount of a bacterial cell and a tumor penetrating agent, wherein administration treats the cancer in the subject, wherein the tumor penetrating agent is a hyaluronidase polypeptide, wherein the combined effective amount is effective to increase tumor penetration by the bacterial cell relative to absence of the tumor penetrating agent, and wherein said tumor penetrating agent is not expressed by said bacterial cell, wherein the tumor penetrating agent is formulated in combination with a pharmaceutically acceptable carrier.
A method of stimulating an immune system in a subject comprising administering to the subject a combined effective amount of a bacterial cell and a tumor penetrating agent, wherein administration of the bacterial cell and the tumor penetrating agent stimulates the immune system of the subject, wherein the tumor penetrating agent is a hyaluronidase polypeptide, and wherein the combined effective amount is effective to increase tumor penetration by the bacterial cell relative to absence of the tumor penetrating agent, wherein said tumor penetrating agent is not expressed by said bacterial cell, wherein the tumor penetrating agent is formulated in combination with a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.