PH-sensitive lipid nanoparticles for encapsulation of anticancer drugs and microRNA and use thereof
AssigneeNational Yang Ming Chiao Tung University
InventorYu-Li Lo
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Abstract
Currently, the present invention provides a pH-sensitive lipid nanoparticle, comprising: a nanoparticle core composed of a mixture of lipid and/or surfactant, and the surface of the nanoparticle core comprising: a imine-omPEG, the imine is a pH-sensitive linker; and a PEG-peptide, wherein the peptide is selected from the group consisting of a RF peptide, a K peptide, and a H peptide; wherein the RF peptide is a potent CPP, the K peptide is a mitochondria-targeting peptide and the H peptide is a cancer specific binding peptide; a lipid, inside the nanoparticle core; wherein the lipid nanoparticle encapsulating a targeting agent.
Claims14
A pH-sensitive lipid nanoparticle, comprising:
- a surface of the lipid nanoparticle;
- and
- a targeting agent inside the lipid nanoparticle,
- wherein the surface comprising:
- an imine-omPEG, the imine is a pH-sensitive linker;
- a PEG-RF peptide, wherein the RF peptide is a potent cell-penetrating peptide (CPP) and has an amino acid sequence of SEQ ID NO:1;
- a PEG-K peptide, wherein the K peptide is a mitochondria-targeting peptide) and has an amino acid sequence of SEQ ID NO:2;
- and
- a PEG-H peptide, wherein the H peptide is a cancer specific binding peptide, a nerve/glial antigen 2 (NG2) proteoglycan binding peptide, and has an amino acid sequence of SEQ ID NO:3,
- wherein the lipid nanoparticle is composed of a lipid, a cationic lipid, a surfactant, or a phospholipid.
Dependencies are inferred from the claim text.