Drug delivery device
AssigneeNational University Corporation Tokyo Medical and Dental University
InventorsAkira Matsumoto, Hiroko Matsumoto, Takayoshi Suganami, Miyako Tanaka, Yuji Miyahara
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Abstract
An improved device capable of releasing a drug in response to stimuli such as a glucose concentration is provided. Provided is a drug delivery device, including a porous body such as a hollow fiber having biocompatibility and drug permeability, a stimuli-responsive gel composition filling inside of the porous body, and a drug surrounded by the gel composition inside of the porous body.
Claims15
A drug delivery device comprising a porous body having biocompatibility and drug permeability, a stimuli-responsive gel composition filling inside of the porous body, and a drug surrounded by the gel composition inside of the porous body, wherein the gel composition is a copolymer gel composition comprising N-isopropylmethacrylamide (NIPMAAm) and 4-(2 acrylamido-ethylcarbamoyl)-3-fluorophenylboronic acid (AmECFPBA),
- wherein the porous body is in the form of a hollow fiber,
- wherein the hollow fiber is made of an ultrafiltration membrane, and the ultrafiltration membrane has a molecular weight cut-off of not more than 10,000 daltons, and
- wherein the porous body has an outer diameter of 100 to 2,000 μm, an inner diameter of 50 to 1,950 μm, and a length of 0.1 to 100 mm.
Dependencies are inferred from the claim text.