Valerian composition and related methods

A composition comprising a solid oral pharmaceutical dosage form comprising:

• 15% w/w to 45% w/w valerian;
• 1% w/w to 20% w/w acidifying agent;
• and
• 1% w/w to 15% w/w of a pharmaceutically acceptable hydrogel-forming polymer;
• wherein the valerian and acidifying agent are blended together in a matrix of the hydrogel-forming polymer, the acidifying agent being in an amount sufficient to impart a pH of 2 to 5 to the matrix;
• the acidifying agent including at least one acid selected from the group consisting of citric acid, succinic acid, tartaric acid, phosphoric acid, and hydrochloric acid;
• the hydrogel forming polymer including at least one polymer selected from the group consisting of a carboxymethylcellulose, a methylcellulose, a hydroxypropylcellulose, a hydroxypropylmethylcellulose, a hyaluronate, an alginate, a pectin, a poloxamer, a poloxamine, an ethylene vinyl acetate, a polyethylene glycol, a dextran, a polyvinylpyrrolidone, a chitosan, a polyvinylalcohol, a propylene glycol, a polyvinylacetate, a polylactic acid, and a polyhydroxybutyric acid;
• the pharmaceutical dosage form being selected from a tablet and a capsule;
• wherein the amount of acidifying agent makes the pharmaceutical dosage form storage stable by reducing degradation of the valerian when the pharmaceutical dosage form is stored at 25 degrees C. and 60% relative humidity.