Staphylococcus pseudintermedius virulence factor compositions

A multivalent immunogenic therapeutic composition, consisting essentially of a recombinant attenuated immunoevasive Staphylococcus pseudintermedius Protein A (SEQ ID NO:2), a recombinant attenuated immunoevasive Staphylococcus pseudintermedius Leukotoxin S (SEQ ID NO:4), a recombinant attenuated immunoevasive Staphylococcus pseudintermedius Nucleotidase adenosine synthase protein (AdsA) (SEQ ID NO:6), a recombinant attenuated immunoevasive Staphylococcus pseudintermedius coagulase (SEQ ID NO:8), a recombinant attenuated immunoevasive Staphylococcus pseudintermedius Leukotoxin F (SEQ ID NO:10), and a recombinant attenuated immunoevasive Staphylococcus pseudintermedius exotoxin 15 (SEQ ID NO:12);

• and
• optionally, one or more suitable pharmaceutical or veterinary excipients and carriers.

A multivalent chimeric protein comprising the sequence set forth as SEQ ID NO:

• 14.

An immunogenic composition, comprising:

• one or more recombinant proteins selected from the group consisting of a recombinant attenuated Staphylococcus pseudintermedius Protein A (SEQ ID NO:2) and a recombinant attenuated Staphylococcus pseudintermedius Leukotoxin S (SEQ ID NO:4);
• and
• one or more of a suitable pharmaceutical or veterinary adjuvant, a suitable pharmaceutical or veterinary excipient, and a suitable pharmaceutical or veterinary carrier.

An immunogenic composition, consisting essentially of a recombinant attenuated Staphylococcus pseudintermedius Protein A (SEQ ID NO:2), a recombinant attenuated Staphylococcus pseudintermedius Leukotoxin S (SEQ ID NO:4), a recombinant attenuated Staphylococcus pseudintermedius Nucleotidase adenosine synthase protein (AdsA) (SEQ ID NO:6), a recombinant attenuated Staphylococcus pseudintermedius coagulase (SEQ ID NO:8), a recombinant attenuated Staphylococcus pseudintermedius Leukotoxin F (SEQ ID NO:10), and a recombinant attenuated Staphylococcus pseudintermedius exotoxin 15 (SEQ ID NO:12);

• and
• one or more of a suitable pharmaceutical or veterinary adjuvant, a suitable pharmaceutical or veterinary excipient, and a suitable pharmaceutical or veterinary carrier.