Methods and compositions for treating aging-associated conditions
AssigneesThe Board of Trustees of the Leland Stanford Junior University, The United States of America as represented by the Department of Veterans Affairs
InventorsAnton Wyss-Coray, Joseph M. Castellano
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Abstract
Methods of treating an adult mammal for an aging-associated condition are provided. Aspects of the methods include enhancing a TIMP activity, e.g., a TIMP2 activity, in the mammal in a manner sufficient to treat the adult mammal for the aging-associated condition. Also provided are compositions for use in practicing methods of the invention. A variety of aging-associated conditions may be treated by practice of the methods, which conditions include cognitive impairments.
Claims19
A method of ameliorating a symptom of aging-associated cognitive impairment or decline in an adult mammal, the method comprising:
- administering a Tissue inhibitor of metalloproteinase (TIMP) polypeptide or a nucleic acid encoding a TIMP polypeptide to the mammal, thereby enhancing a TIMP activity in the mammal in a manner sufficient to ameliorate a symptom of aging-associated cognitive impairment or decline.
Dependencies are inferred from the claim text.