GLP-1 polypeptide having GLP-1 receptor agonist activity and use thereof
AssigneeLiu Jianning
InventorsLiu Jianning, Wang Jingyi
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Abstract
The present application belongs to the field of medicine. The present application relates to a GLP-1 polypeptide having GLP-1 receptor agonist activity and the use thereof. The present application further relates to a pharmaceutical composition comprising the GLP-1 polypeptide. In particular, the present application relates to a GLP-1 polypeptide having GLP-1 receptor agonist activity, or a pharmaceutically acceptable salt thereof, characterized in that the GLP-1 polypeptide has a mutation from threonine to proline at the position corresponding to the 13th position of the amino acid sequence of GLP-1.
Claims8
A GLP-1 polypeptide having GLP-1 receptor agonist activity, or a pharmaceutically acceptable salt thereof, characterized in that the GLP-1 polypeptide has a mutation from threonine to proline at the position corresponding to the 13th position of the amino acid sequence of GLP-1,
- wherein the GLP-1 polypeptide is Gly8-Pro13-GLP-1(1-37), Gly8-Pro13-GLP-1(7-37), Gly8-Pro13-GLP-1(7-36)NH2, Ser8-Pro13-GLP-1(1-37), Ser8-Pro13-GLP-1(7-37), Ser8-Pro13-GLP-1(7-36)NH2, Thr8-Pro13-GLP-1(1-37), Thr8-Pro13-GLP-1(7-37) or Thr8-Pro13-GLP-1(7-36)NH2.
Dependencies are inferred from the claim text.