Method for the treatment or prevention of osteoarthritis
AssigneeChondropeptix B.V.
InventorsTim Johannes Maria Welting, Marjolein Maria Johanna Caron
Life of this patent
Estimating the term…
Abstract
The present invention is in the field of medicine and provides means and methods for the treatment, prevention or amelioration of osteoarthritis. More in particular, it provides a peptide for use in the treatment, amelioration or prevention of osteoarthritis, wherein the peptide is between 12 and 28 amino acids in length and comprises an amino acid sequence according to SEQ ID NO: 16 or a variant thereof according to formula 2, wherein the amino acid sequence of said peptide is comprised in SEQ ID NO: 34 or a variant thereof according to formula 1.
Claims5
A method of treating a subject at risk of developing osteoarthritis, the method comprising:
- administering to the subject a peptide;
- wherein the peptide is between 12 and 28 amino acids in length and comprises the full length of the amino acid sequence according to SEQ ID NO:
- 16 or comprises the full length of a variant of SEQ ID NO:
- 16 according to formula 2,
- wherein the amino acid sequence of the peptide is comprised in SEQ ID NO:
- 34 or a variant thereof according to formula 1,
- wherein formula 1 is:
- X1 X2 X3 G Y X4 A X5 Y S E G X6 S X7 X8 X9 L X10 X11 X12 M N A T X13 H A (SEQ ID NO:
- 47)
- wherein
- X1=A or I or L or M or Y or V or E or H or K or Q or R,
- X2=P or Y or M,
- X3=E or R or H or K or N or P or Q or S or T or I or L or M or V,
- X4=A or E or Q or R or S,
- X5=Y or N or D,
- X6=E or A or Q,
- X7=A or D or E or H or K or S,
- X8=F or A or D or E or H or Q or R or S,
- X9=P or M,
- X10=N or A or D or S or T or E or Q or R or I or V,
- X11=S or A or D or E or H or K or N or P or Q or T,
- X12=Y or D or G or H or N or R or S or T, and
- X13=N or F or W or Y or H or K or R;
- and
- wherein Formula 2 is:
- Y S E G X6 S X7 X8 X9 L X10 X11 (SEQ NO:
- 48)
- wherein
- X6=E or A or Q,
- X7=A or D or E or H or K or S,
- X8=F or A or D or E or H or Q or R or S,
- X9=P or M,
- X10=N or A or D or S or T or E or Q or R or I or V, and
- X11=S or A or D or E or H or K or N or P or Q or T.
A method of treating a subject at risk of developing osteoarthritis, the method comprising:
- administering to the subject a linear retro-inverso peptide or retro-inverso peptide;
- wherein the linear retro-inverso peptide or retro-inverso peptide is between 12 and 28 amino acids in length and comprises the full length of the retro-inverso of the amino acid sequence according to SEQ ID NO:
- 16 or comprises the full length of the retro-inverso of a variant of SEQ ID NO:
- 16 according to formula 2,
- wherein the amino acid sequence of the linear retro-inverso peptide or retro-inverso is comprised in the retro-inverso of SEQ ID NO:
- 34 or a variant thereof according to formula 1,
- wherein formula 1 is:
- (SEQ ID NO:
- 47)
- X1 X2 X3 G Y X4 A X5 Y S E G X6 S X7 X8 X9 L X10
- X11 X12 M N A T X13 H A
- wherein
- X1=A or I or L or M or Y or V or E or H or K or Q or R,
- X2=P or Y or M,
- X3=E or R or H or K or N or P or Q or S or T or I or L or M or V,
- X4=A or E or Q or R or S,
- X5=Y or N or D,
- X6=E or A or Q,
- X7=A or D or E or H or K or S,
- X8=F or A or D or E or H or Q or R or S,
- X9=P or M,
- X10=N or A or D or S or T or E or Q or R or I or V,
- X11=S or A or D or E or H or K or N or P or Q or T,
- X12=Y or D or G or H or N or R or S or T, and
- X13=N or F or W or Y or H or K or R;
- and
- wherein Formula 2 is:
- Y S E G X6 S X7 X8 X9 L X10 X11 (SEQ ID NO:
- 48)
- wherein
- X6=E or A or Q,
- X7=A or D or E or H or K or S,
- X8=F or A or D or E or H or Q or R or S,
- X9=P or M,
- X10=N or A or D or S or T or E or Q or R or I or V, and
- X11=S or A or D or E or H or K or N or P or Q or T.
Dependencies are inferred from the claim text.