Peptide analogues with branched amino acid probe(s)

A peptide analogue comprising a peptide and one or more branched amino acid probes,

• wherein said peptide is selected from the group consisting of glucagon-like peptide-1 (GLP-1), GLP-1 (7-37), GLP-1 (7-33) and exendin-4,
• wherein said one or more branched amino acid probes comprises a first amino-alkyl amino acid residue,
• said first amino-alkyl amino acid residue optionally being covalently linked to a second amino-alkyl amino acid residue, or to a second and a third amino-alkyl amino acid residue, to form a linear chain of 2 or 3 amino-alkyl amino acid residues,
• wherein the side chain of one or more of said first, second and/or third amino-alkyl amino acid residues are each modified by attaching to the side chain amino group a molecule independently selected from the group consisting of AAAq-AAA (SEQ ID NO:
• 168);
• (aa3)p-AAAq (SEQ ID NOs:
• 169-174);
• AAAq-(aa3)p (SEQ ID NOs:
• 175-180);
• [(aa3)-AAA]p (SEQ ID NOs:
• 181 and 182);
• and [AAA-(aa3)]p (SEQ ID NOs:
• 183 and 184);
• wherein q is a number selected from 0, 1, 2 and 3;
• p is a number selected from 1, 2 and 3;
• AAA is an amino-alkyl amino acid residue;
• and (aa3) is an amino acid residue independently selected from Arg, His, Gly and Ala,
• wherein said amino-alkyl amino acid residues are optionally acetylated,
• wherein said first amino-alkyl amino acid residue is covalently linked to the N-terminus of said peptide, covalently linked to the C-terminus of said peptide, or attached to the side chain amino group of an amino-alkyl amino acid residue within said peptide,
• with the proviso that said one or more branched amino acid probes consists of 2 to 9 amino acid residues.