Pharmaceutical composition and health functional food comprising oat extract avenanthramide C or derivative thereof as effective ingredient for prevention or treatment of neurodegenerative disease
AssigneesIndustry Foundation of Chonnam National University, Republic of Korea (Management: Rural Development Administration)
InventorsJi Hoon Jo, Hyung Seok Kim, Yu Young Lee
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Abstract
A pharmaceutical composition and a health functional food including an oat extract as an effective ingredient for prevention or treatment of neurodegenerative disease. More specifically, the present invention provides a pharmaceutical composition and a health functional food including an oat extract such as avenanthramide C or a derivative thereof, for example, avenanthramide methyl ester as an effective ingredient for prevention or treatment of Alzheimer's disease.
Claims10
A method for treatment of Alzheimer's disease, the method comprising:
- first-measuring at least one of an activity of glycogen synthase kinase-3β (GSK3β) and long-term potentiation (LTP) of a subject having the Alzheimer's disease;
- administering to the subject an amount of a composition, effective to reduce GSK3β activity and/or to induce long-term potentiation, including an oat extract having avenanthramide C represented by Formula 1 or Formula 2:
- and
- after the administering, second-measuring said at least one of the activity of GSK3β and the long-term potentiation (LTP) to determine if the activity of GSK3β is reduced and/or the long-term potentiation (LTP) is induced in order to determine the treatment of the Alzheimer's disease.
Dependencies are inferred from the claim text.