Inhaled respiratory probiotics for lung diseases of infancy, childhood and adulthood
AssigneeThe UAB Research Foundation
InventorsCharitharth Vivek Lal, Namasivayam Ambalavanan, Amit Gaggar, Casey Morrow
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Abstract
The respiratory microbiomes of neonates and those with bronchopulmonary disease have been characterized. Provided are probiotic compositions, which can include at least one living bacterial strain and at least one killed bacterial strain, that can comprise a combination of Lactobacilli species, 5 that when delivered to the bronchi or lungs of a patient can provide a reduction in the symptoms of a bronchopulmonary disease.
Claims26
A pharmaceutical composition comprising a probiotic bacterial population, wherein the bacterial population consist of the strains comprising at least one Lactobacillus rhamnosus ATCC 53103, Lactobacillus plantarum wcfs1 ATCC BAA-793, and Lactobacillus acidophilus ATCC 4356, wherein the combination of the Lactobacillus species reduces neutrophilic inflammation when delivered to an animal or human subject.
A method of reducing a bronchopulmonary disease of a patient, the method comprising the step of administering to the patient in need thereof an effective dose of a pharmaceutical composition comprising a probiotic bacterial population, wherein the bacterial population consists of the strains Lactobacillus rhamnosus ATCC 53103, Lactobacillus plantarum wcfs1 ATCC BAA-793, and Lactobacillus acidophilus ATCC 4356, wherein the combination of the Lactobacillus species reduces neutrophilic inflammation in the patient.
A kit comprising:
- at least one container and a pharmaceutical composition therein, said pharmaceutical composition comprising a probiotic bacterial population, wherein the bacterial population consists of the strains Lactobacillus rhamnosus ATCC 53103, Lactobacillus plantarum wcfs1 ATCC BAA-793, and Lactobacillus acidophilus ATCC 4356, and instructions for delivery of an effective amount of the composition to a patient in need thereof.
Dependencies are inferred from the claim text.