Materials and methods for increasing immune responses
AssigneeMayo Foundation for Medical Education and Research
InventorsProtul Shrikant, Leena Chaudhuri
Life of this patent
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Abstract
Provided herein are materials and methods for treating a cancer and/or an infection in a mammal. One or more mitochondrial protein uncoupling protein 2 (UCP2) inhibitors can be administered to a mammal to enhance an immune response produced against an antigen (e.g., a tumor associated antigen or a pathogen associated antigen) present within the mammal.
Claims15
A method for treating cancer in a mammal, said method comprising:
- (a) contacting a tumor associated antigen, a co-stimulatory molecule selected from the group consisting of B7.1, CD28, and inducible co-stimulator (ICOS), a cytokine selected from the group consisting of IL-12, IL-2, and IFN-γ, and a UCP2 inhibitor to naïve CD8+T cells obtained from said mammal to generate effector CD8+T cells specific for the antigen ex vivo;
- and
- (b) administering the antigen specific effector CD8+T cells to said mammal.
A method of generating antigen specific CD8+T cells ex vivo, said method comprising contacting a tumor associated antigen, a co-stimulatory molecule selected from the group consisting of B7.1, CD28, and ICOS, a cytokine selected from the group consisting of IL-12, IL-2, and IFN-γ, and a UCP2 inhibitor to nave CD8+T cells obtained from a mammal.
Dependencies are inferred from the claim text.