Octasaccharides and uses thereof
AssigneeAcademia Sinica
InventorsShang-Cheng Hung, Kenji Kadomatsu, Kazuma Sakamoto, Yen-Chun Ko, Cheng-Fang Tsai, Chiao-Yuan Fan
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Abstract
Disclosed herein is a sulfated octasacchande of formula (I), a pharmaceutically acceptable salt, solvate or ester thereof: wherein R1 is —NHAc or —NHSO3H; and R2 and R3 are independently H, or —SO3H. Also encompasses herein is a method of treating neuron injury and/or diseases associated with a disrupted autophagy flux. The method includes administering an effective amount of the sulfated octasaccharide of formula (I) to a subject in need of such treatment.
Claims11
A sulfated octasaccharide of formula (I), a pharmaceutically acceptable salt, solvate or ester thereof:
- wherein R1 is —NHAc or —NHSO3H;
- and R2 and R3 are independently H, or —SO3Na.
Dependencies are inferred from the claim text.