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US 11,141,426 B2Granted
Compositions and methods comprising growth factors, chondroitin and glucosamine for degenerative disc regeneration
AssigneeUniversity Health Network
InventorWilliam Mark Erwin
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Abstract
There is disclosed herein compositions, methods, uses and systems for reducing pain in a patient that emanates from a body area, preferably spine or joint. Methods of treatment or prevention are described for a disease or condition selected from degenerative disc disease, disc injury, pain, arthritis, or suspected arthritis.
Claims31
A pharmaceutical composition comprising:
- i) chondroitin or chondroitin sulfate present at about 0.1% to about 2.0% by weight of the composition;
- ii) glucosamine or glucosamine hydrochloride present at about 1% to about 25% by weight of the composition;
- iii) dextrose;
- and
- iv) connective tissue growth factor (CTGF) at a concentration of about 50 ng/mL to about 500 ng/mL of the composition as the sole growth factor in the composition;
- transforming growth factor beta 1 (TGF-β1) at a concentration of about 1 ng/mL to about 100 ng/mL of the composition as the sole growth factor in the composition;
- or
- CTGF at a concentration of about 50 ng/mL to about 500 ng/mL of the composition and TGF-β1 at a concentration of about 1 ng/mL to about 100 ng/mL of the composition as the only growth factors in the composition;
- wherein the composition is suitable for intervertebral disc (IVD) injection;
- and wherein the composition promotes regeneration of a degenerative IVD nucleus pulposus (NP) and/or increases viability of NP cells within the degenerative IVD.
7 more elements
Dependencies are inferred from the claim text.