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US 11,141,424 B2Granted
Bladder instillation composition containing chondroitin sulfate (20 mg/ml), hyaluronic acid (16 mg/ml) and a phosphate buffer (pH 6.1 to 7.9) with increased storage stability for treating cystitis
AssigneeFarco-Pharma GmbH
InventorAndreas Meier
Life of this patent
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Abstract
The invention relates to a composition, in particular a pharmaceutical composition, which is suitable in particular for the prophylactic and/or therapeutic treatment preferably of inflammatory diseases of the urogenital tract, in particular inflammatory diseases of the bladder, preferably cystitis, to the uses thereof, to a storage or application device relating to same, to a packaging unit, and finally to a kit which is designed in particular as an instillation system.
Claims20
A composition for the treatment of inflammatory diseases of the urogenital tract,
- wherein the composition comprises in combination and in effective amounts each:
- (a) at least one of chondroitin sulfate and a physiologically compatible chondroitin sulfate salt in a concentration of (20±2) mg/ml as component (a),wherein the chondroitin sulfate or the physiologically compatible chondroitin sulfate salt each have a weight-average molecular weight Mw within the range of from 10 kDa to 200 kDa;
- (b) at least one of hyaluronic acid and a physiologically compatible hyaluronic acid salt (hyaluronate) in a concentration of (16±1.6) mg/ml as component (b), wherein the hyaluronic acid or the physiologically compatible hyaluronic acid salt each have a weight-average molecular weight Mw within the range of from 10 kDa to 500 kDa;
- (c) a dihydrogen phosphate/monohydrogen phosphate buffer system as component (c), wherein the composition comprises the dihydrogen phosphate/monohydrogen phosphate buffer system in a total concentration of dihydrogen phosphate/monohydrogen phosphate buffer system of (1.75±1.65) mg/ml;
- wherein the composition is set to a pH value within the range of from 6.1 to 7.9.
2 more elements
Dependencies are inferred from the claim text.