Use of iminosugars as prophylactic and therapy against COVID-19 / SARS-CoV-2
AssigneeThe Penn State Research Foundation
InventorSuresh Kuchipudi
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Abstract
Provided are methods for prophylaxis or treatment of SARS-CoV-2 by administering a composition comprising one or more iminosugars to an individual in need thereof. The compositions may be administered to an individual who is at risk of becoming infected by SARS-CoV-2, or has been diagnosed with a SARS-CoV-2 infection. The iminosugars can inhibit SARS-CoV-2 cell entry and replication. The iminosugars potentiate co-administered antiviral agents, such as nucleoside analogs.
Claims12
A method for treatment of or to inhibit the onset of a SARS-CoV-2 infection comprising administering to an individual in need thereof an effective amount of a composition comprising one or more iminosugars, selected from the group consisting of acarbose, miglitol, castanospermine and a combination thereof, and Remdesivir, wherein the one or more iminosugars potentiates the effect of Remdesivir.
Dependencies are inferred from the claim text.