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AssigneeMerck Sharp & Dohme Corp.
InventorsJohn P. Caldwell, Ginny Dai Ho, Sookhee N. Ha, Sandra J. Koseoglu, Marc A. Labroli, Sang Ho Lee, Christina Madsen-Duggan, Mihir Mandal, Jianping Pan, Weidong Pan, Terry Roemer, Jing Su, Christopher Michael Tan, Zheng Tan, Hao Wang, Christine Yang, Shu-Wei Yang
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Novel compounds of the structural formula I, and the pharmaceutically acceptable salts thereof, are inhibitors of TarO and may be useful in the prevention, treatment and suppression of diseases mediated by TarO, such as bacterial infections, including gram negative bacterial infections and gram positive bacterial infections such as MRSA and MRSE, alone or in combination with a β-lactam antibiotic.
A method of treating a bacterial infection in a patient by administering to a patient in need thereof, a synergistic combination of a TarO inhibitor compound or a pharmaceutically acceptable salt thereof, and a β-lactam antibiotic;
Dependencies are inferred from the claim text.