Treatment of vasculopathy with prostacyclin and mesenchymal stem cells
AssigneeUnited Therapeutics Corporation
InventorsRoger Jeffs, Thomas Petersen, Roger M. Ilagan, Michael Wade
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Abstract
Provided are methods for treating or preventing vasculopathy in a subject in need thereof, comprising administering to the subject a prostacyclin and a mesenchymal stem cell (MSC) or a MSC-conditioned culture medium or administering to the subject a MSC or a MSC-conditioned culture medium that has treated with prostacyclin. Pharmaceutical compositions suitable for such treatments are also provided.
Claims10
A method for treating or preventing vasculopathy in a subject in need thereof, comprising administering to the subject a prostacyclin and a composition comprising (i) a part of a culture medium that has been in contact with a mesenchymal stem cell (MSC) and contains one or more components of the MSC, wherein the component(s) of the MSC comprises a microRNA, a messenger RNA, a non-coding RNA, a mitochondria, a growth factor, or combinations thereof, or (ii) an exosome derived from the MSC, wherein the vasculopathy is selected from the group consisting of pulmonary arterial hypertension (PAH), peripheral vascular disease (PVD), critical limb ischemia (CLI), coronary artery disease and diabetic vasculopathy.
Dependencies are inferred from the claim text.