Mitofusin activators and methods of use thereof
AssigneeMitochondria Emotion, Inc.
InventorGerald W. Dorn, II
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Abstract
Compositions including small molecule mitofusin activators are described. The mitofusin activators are useful for treating diseases or disorders associated with a mitochondria-associated disease, disorder, or condition such as diseases or disorders associated with mitofusin 1 (MFN1) and/or mitofusin 2 (MFN2), or mitochondrial dysfunction. Methods of treatment, pharmaceutical formulations, and screening methods for identifying compounds that activate mitochondrial fusion are also described.
Claims7
A method comprising:
- administering a therapeutically effective amount of a composition comprising one or more of a mitofusin activator or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof to a subject having or suspected of having a mitochondria-associated disease, disorder or condition, the mitofusin activator having Formula 1 or Formula 2
- wherein R1 is selected from:
- and wherein R2 is selected from
- wherein R1 is not cyclohexyl or methylcyclohexyl when the mitofusin activator has Formula 2;
- and
- wherein R1 is not tetrahydro-2H-pyran-4-yl or 3-methyltetrahydro-2H-pyran-4-yl when R2 is phenyl and the mitofusin activator has Formula 2.
A composition comprising one or more of a mitofusin activator or a pharmaceutically acceptable salt thereof, the mitofusin activator having Formula 1 or Formula 2
- or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof,
- wherein R1 is selected from:
- and wherein R2 is selected from
- wherein R1 is not cyclohexyl or methylcyclohexyl when the mitofusin activator has Formula 2;
- and
- wherein R1 is not tetrahydro-2H-pyran-4-yl or 3-methyltetrahydro-2H-pyran-4-yl when R2 is phenyl and the mitofusin activator has Formula 2.
Dependencies are inferred from the claim text.