Prodrug compositions, prodrug nanoparticles, and methods of use thereof

A composition for in vivo delivery of a compound to a target cell, the composition comprising a non-liposomal particle and at least one prodrug, wherein:

• (a) the particle has an outer surface that is a membrane comprised of the at least one prodrug, about 100 mol % to about 60 mol % phospholipid, and a homing ligand, and an inner core comprising a surfactant;
• (b) the particle has a hydrodynamic diameter that is about 10 to about 20 nm, as measured by dynamic light scattering;
• (c) the prodrug comprises a compound of less than about 3000 da linked to an acyl moiety of a phosphoglyceride, wherein the compound may be released from the phosphoglyceride backbone via enzyme cleavage;
• and
• (d) the particle can leave blood vessels while circulating through the body.