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US 11,141,378 B2Granted
Lipid formulations for nucleic acid delivery
AssigneeArbutus Biopharma Corporation
InventorsEdward Yaworski, Kieu Lam, Lloyd Jeffs, Lorne Palmer, Ian MacLachlan
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Abstract
The present invention provides novel, stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles. More particularly, the present invention provides stable nucleic acid-lipid particles (SNALP) comprising a nucleic acid (such as one or more interfering RNA), methods of making the SNALP, and methods of delivering and/or administering the SNALP.
Claims30
A nucleic acid-lipid particle consisting essentially of:
- (a) an RNA;
- (b) a cationic lipid having a protonatable tertiary amine;
- (c) a mixture of a phospholipid and cholesterol of from 30 mol % to 55 mol % of the total lipid present in the particle, wherein the phospholipid consists of from 3 mol % to 15 mol % of the total lipid present in the particle;
- and
- (d) a polyethyleneglycol (PEG)-lipid conjugate consisting of from 0.1 mol % to 2 mol % of the total lipid present in the particle.
2 more elements
Dependencies are inferred from the claim text.