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US 11,141,376 B2Granted
Circulation of components during microfluidization and/or homogenization of emulsions
AssigneeNovartis AG
InventorsHarald Rueckl, Hanno Scheffczik, Barbara Santry
Life of this patent
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Abstract
An improved method for the manufacture of an oil-in-water emulsion involves circulation of emulsion components between a first container and a second container via a homogenizer and/or via a microfluidization device. Usefully, all of the emulsion components from the first container are emptied before being returned.
Claims24
A method for the manufacture of an emulsion, the method comprising the step of:
- (i) formation of a first emulsion having a first average oil droplet size by circulation, comprising (a) at least one type I circulation of transferring the first emulsion components between a first container and a homogenizer and (b) at least one type II circulation of transferring the first emulsion components from a first container to a second container through a homogenizer, and then returning them from the second container to the first container through the same homogenizer.
Dependencies are inferred from the claim text.