Heart failure evaluation method and diagnosis device
AssigneeTeijin Pharma Limited
InventorSadayoshi Matsumoto
Life of this patent
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Abstract
Provided are a means to detect a plurality of dynamics, a processing unit that calculates a temporal change in the detected dynamics, and an evaluation device that determines exacerbation of clinical conditions in heart failure of a patient based on the calculated change in the patient's dynamics over time. The present invention makes it possible to detect, early and with high accuracy, that the onset of acute heart failure is imminent.
Claims15
A diagnosis device for providing information related to changes in clinical conditions of a patient having a chronic heart failure, the diagnosis device comprising:
- one or more detectors configured to continuously detect a plurality of physiological indexes of the patient that are different from each other, in a first observation period and in a second observation period;
- and
- a processor configured to:
- determine whether to generate the information for the patient according to the first observation period in which a compensatory mechanism of the patient is indicated as functioning or to the second observation period during which a breakdown of the compensatory mechanism is indicated, wherein the compensatory mechanism is a patient function which aims at improving the clinical conditions which deteriorate due to falling of a heart pumping function of the patient, and
- generate and output the information that a medical professional uses for at least one of an observation or a diagnosis of the patient, based on the plurality of physiological indexes,
- wherein the processor is further configured to generate the information so that at least one aspect of the following (1) to (4) aspects is made different between generating the information in the first observation period and generating the information in the second observation period:
- (1) a selection of physiological indexes among the plurality of physiological indexes to be used for the generating the information,
- (2) an order of priority of each of the selected physiological indexes used for the generating the information,
- (3) a weight for each of the selected physiological indexes, respectively, used for the generating the information, and
- (4) a determination threshold for each of the selected physiological indexes, respectively, used for the generating the information.
A diagnosis device for providing information related to changes in clinical conditions of a patient having a chronic heart failure, the diagnosis device comprising:
- a processor configured to:
- based on the patient being in a state in which a compensatory mechanism of the patient is assumed to be functioning, generate and output the information for at least one of a prediction in an exacerbation of the patient or a diagnosis of the patient, based on information of a physiological index including at least one of (a) an augmentation state of a sympathetic nervous system, (b) a state of a vasoconstriction, or (c) at least one of a respiratory frequency, an index indicating a respiratory stability, or an amount of a ventilation, of the patient,
- wherein the compensatory mechanism of the patient is a patient function which aims at improving the clinical conditions which deteriorate due to falling of a heart pumping function of the patient.
A diagnosis device for providing information related to changes in clinical conditions of a patient having a chronic heart failure, the diagnosis device comprising:
- one or more detectors configured to continuously detect a plurality of physiological indexes of the patient that are different from each other;
- and
- a processor configured to generate and output the information that a medical professional uses for at least one of an observation or a diagnosis of the patient, based on the plurality of physiological indexes,
- wherein the processor is further configured to generate the information so that at least one aspect of following (1) to (4) aspects is made different according to one or more of a progressive stage of the chronic heart failure of the patient, a severity of the chronic heart failure of the patient, and background diseases of the patient:
- (1) a selection of physiological indexes among the plurality of physiological indexes to be used for the generating the information,
- (2) an order of priority of each of the selected physiological indexes used for the generating the information,
- (3) a weight for each of the selected physiological indexes, respectively, used for the generating the information, and
- (4) a determination threshold for each of the selected physiological indexes, respectively, used for the generating the information.
A diagnosis device for providing information related to changes in clinical conditions of a patient having a chronic heart failure, the diagnosis device comprising:
- a plurality of detectors configured to continuously detect a plurality of physiological indexes of the patient that are different from each other;
- and
- a processor configured to generate and output the information that a medical professional uses for at least one of an observation or a diagnosis of the patient, based on the plurality of physiological indexes,
- wherein the processor is further configured to generate the information based on the plurality of physiological indexes including at least one of (I) at least one of a respiratory frequency, an index indicating a respiratory stability, or an amount of ventilation of the patient, or (II) an index indicating an augmentation state of a sympathetic nervous system of the patient.
A diagnosis device for providing information related to changes in clinical conditions of a patient having a chronic heart failure, the diagnosis device comprising:
- a plurality of detectors configured to continuously detect a plurality of physiological indexes of the patient that are different from each other;
- and
- a processor configured to generate and output the information that a medical professional uses for at least one of an observation or a diagnosis of the patient, based on the plurality of physiological indexes,
- wherein the processor is further configured to generate the information based on the plurality of physiological indexes including at least one of (I) at least one of a respiratory frequency, an index indicating a respiratory stability, or an amount of a ventilation, of the patient, or (II) a cardiac output of the patient.
A diagnosis device for providing information related to changes in clinical conditions of a patient having a chronic heart failure, the diagnosis device comprising:
- a plurality of detectors configured to continuously detect a plurality of physiological indexes of the patient that are different from each other;
- and
- a processor configured to generate and output the information that a medical professional uses for at least one of an observation or a diagnosis of the patient, based on the plurality of physiological indexes,
- wherein the processor is further configured to generate the information based on the plurality of physiological indexes including at least one of (I) at least one of a respiratory frequency, an index indicating a respiratory stability, or an amount of a ventilation, of the patient, (II) an index indicating an augmentation state of a sympathetic nervous system of the patient, or (III) a cardiac output of the patient.
Dependencies are inferred from the claim text.