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US 11,136,600 B2Granted
Eukaryotic cell with increased production of fermentation product
AssigneeDsm IP Assets B.V.
InventorsIoannis Papapetridis, Jacobus Thomas Pronk, Antonius Jeroen Adriaan Van Maris, Paul Klaassen
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Abstract
The present invention relates to a eukaryotic cell that is genetically modified comprising one or more heterologous gene encoding: a) D-glucose-6-phosphate dehydrogenase and/or b) 6-phosphogluconate dehydrogenase; and/or c) glucose dehydrogenase, gluconolactonase and gluconate kinase, wherein a), b) and glucose dehydrogenase in c) are NAD+ dependent.
Claims24
A yeast cell that is genetically modified, to comprise one or more heterologous genes encoding
- a) an enzyme having NAD dependent D-glucose-6-phosphate dehydrogenase activity and/or
- b) an enzyme having NAD dependent 6-phosphogluconate dehydrogenase activity;
- and/or
- c) enzymes having, gluconolactonase (E.C. 3.1.1.17), gluconate kinase (E.C. 2.7.1.12), and NAD+dependent glucose dehydrogenase activities (E.C. 1.1.1.118) wherein the yeast cell was capable of alcoholic fermentation before or after being genetically modified to comprise the one or more heterologous genes.
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Dependencies are inferred from the claim text.