Dihydroartemisinin diploid derivative, pharmaceutical composition thereof, and application
AssigneeSoutheast University
InventorsXinsong Li, Ma Si, Longbing Ling
Life of this patent
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Abstract
Disclosed are a dihydroartemisinin dimer derivative, a pharmaceutical composition, and an application thereof. The derivative is an artemisinin dimer used for drugs treating or preventing malaria caused by plasmodium, drugs treating autoimmune diseases such as lupus erythematosus, and anti-tumour drugs, which is a pharmaceutical composition prepared from the dihydroartemisinin dimer derivative and a pharmaceutically acceptable carrier.
Claims3
A method for treating parasitosis, autoimmune disease, tumor, leukemia, toxoplasmosis or skin disease comprising a step of administrating a dihydroartemisinin dimer derivative to a subject in need of treatment;
- wherein the dihydroartemisinin dimer derivative has a general formula (1) or a pharmaceutically acceptable salt thereof:
- wherein X is selected from a group consisting of
- CH2, CH2—CH2, CH2—CH2—CH2, CH2—CH2—CH2—CH2, CH2—S—S—CH2, CH2—CH2—S—S—CH2—CH2, CH2—O—CH2, O—CH2—CH2—O, O—CH2—CH2—CH2—O, O—CH2—CH2—CH2—CH2—O, O—CH2—CH2—O—CH2—CH2—O, O—CH2—CH2—O—CH2—CH2—O—CH2—CH2—O, O—CH2—CH2—SS—CH2—CH2—O—CO—CH2—CH2, O—CH2—CH2—CH2—CH2—O—CO—CH2—CH2, O—CH2—CH2—CH2—CH2—CH2—CH2—O—CO—CH2—CH2, O—CH2—CH2—CH2—O—CO—CH2—CH2, O—CH2—CH2—O—CO—CH2—CH2, NH—CH2—CH2—NH, NH—CH2—CH2—CH2—NH, NH—CH2—CH2—CH2—CH2—NH, NH—CH2—CH2—CH2—CH2—CH2—NH, NH—CH2—CH2—CH2—CH2—CH2—CH2—NH, O—CH2—CH2—S—S—CH2—CH2—O and NH—CH2—CH2—S—S—CH2—CH2—NH;
- and Y is selected from a group consisting of
Dependencies are inferred from the claim text.