Processes for the production of tryptamines
AssigneeNew Atlas Biotechnologies LLC
InventorRyan Protzko
Life of this patent
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Abstract
Disclosed herein are prokaryotic and eukaryotic microbes, including E. coli and S. cerevisiae, genetically altered to biosynthesize tryptamine and tryptamine derivatives. The microbes of the disclosure may be engineered to contain plasmids and stable gene integrations containing sufficient genetic information for conversion of an anthranilate or an indole to a tryptamine. The fermentative production of substituted tryptamines in a whole-cell biocatalyst may be useful for cost effective production of these compounds for therapeutic use.
Claims25
A compound of Formula (I):
- or a pharmaceutically acceptable salt thereof, wherein,
- R1 is selected from H and optionally substituted C1-5alkyl;
- R2 is selected from optionally substituted linear C3-5alkyl;
- and
- R4, R5, R6, and R7 are independently selected from H and —O(P═O)(OH)2, wherein at least one of R4, R5, R6, and R7 is —O(P═O)(OH)2.
A compound selected from the group consisting of:
- or a pharmaceutically acceptable salt of any one thereof.
A pharmaceutical composition, comprising a compound of Formula (I):
- or a pharmaceutically acceptable salt thereof, wherein,
- R1 is selected from H and C1-5alkyl;
- R2 is C3-5alkyl;
- and
- R4, R5, R6, and R7 are independently selected from H and —O(P═O)(OH)2, wherein at least one of R4, R5, R6, and R7 is —O(P═O)(OH)2.
A method of improving perception and mood in a human subject in need thereof, comprising administering to the human subject in need thereof a compound of Formula (I):
- or a pharmaceutically acceptable salt thereof, wherein,
- R1 is selected from H and C1-5alkyl;
- R2 is C3-5alkyl;
- and
- R4, R5, R6, and R7 are independently selected from H and —O(P═O)(OH)2, wherein at least one of R4, R5, R6, and R7 is —O(P═O)(OH)2.
Dependencies are inferred from the claim text.