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US 11,131,681 B2Granted
Method for diagnosing psychiatric disorders
AssigneeDr. Raymond Laboratories, Inc.
InventorsByeong Deog Park, Se Kyoo Jeong, Kyungho Park, Chae Hyeong Park, Kyong Oh Shin
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Abstract
Disclosed herein is a method for predicting or diagnosing psychiatric disorders through analyzing skin tissues samples minimally invasive or non-invasively collected. The method disclosed herein makes it possible to diagnose psychiatric disorders through objective biomarkers at a very early age, without giving pain to subjects because of noninvasive or minimally invasive feature of skin sample collection method.
Claims3
A method for determining a sphingolipid ratio in a subject that comprises:
- preparing a skin tissue sample obtained from the subject, wherein preparing the skin tissue sample includes extracting lipid components,
- analyzing a sphingolipid or sphingolipid metabolite content of the skin tissue sample by running the sphingolipid or sphingolipid metabolite content of the skin tissue sample in one or more of gas chromatography-mass spectrometry (GS-MS), liquid chromatography-mass spectrometry (LS-MS), matrix assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), and time-of-flight secondary Ion mass spectrometry (TOF-SIMS),
- providing a control subject who has a healthy control skin,
- comparing the sphingolipid or sphingolipid metabolite content from the subject with those obtained from the healthy control skin,
- and
- obtaining the sphingolipid ratio, the sphingolipid ratio being a molar ratio of a first sphingolipid of the skin tissue sample to a second sphingolipid of the skin tissue sample,
- wherein the skin tissue sample is obtained by a tape stripping method,
- and
- wherein the molar ratio is a molar ratio of C24:1/C16:1 ceramides, C24:1/C16:0 ceramides, C24/C18 sphingomyelins, or C24/C20 sphingomyelins.
6 more elements
Dependencies are inferred from the claim text.