Anti-infective heterocyclic compounds and uses thereof

A compound of formula I:

• or a pharmaceutically acceptable salt thereof,
• wherein
• A is S;
• X1 is selected from CH and N;
• each of X2, X3, X4 and X5 is CH;
• R1 is selected from the group consisting of
• —H,
• —C1-6 alkyl,
• —C1-6 alkyl-amino wherein the amino group is optionally substituted with one or two C1-6acyl or C1-6alkyl groups,
• and
• —C1-6 alkyl-heterocyclyl wherein the heterocyclyl group is a 5- or 6-membered aliphatic or aromatic heterocycle, optionally benzo-fused, and is optionally substituted with one or more R6 groups;
• R2 is selected from the group consisting of —N(R5)2, —NHR5, —N(R5)C(O)R5, and —N(R5)C(S)N(R5)2;
• R3 is selected from —CF3, —CN, —Cl, —C1-6 alkyl, —C3-6 cycloalkyl, —C(O)NH2, —C(O)NH—C1-6 alkyl, —NH-heterocyclyl, -phenyl, and -heterocyclyl, wherein the heterocyclyl group is a 5- or 6-membered aliphatic or aromatic optionally benzo-fused heterocycle, and wherein R3 is optionally substituted with one of more R6 groups;
• each of R4 and R8 is selected from H, —CN, -halo, —CF3, —C1-6 alkoxy, —CO2—C1-6 alkyl, —NO2, —C1-6 alkyl-NH2, -heterocyclyl, and —CONHm[(CH2)nNH2]2-m, wherein the heterocyclyl group is a 5- or 6-membered aliphatic or aromatic optionally benzo-fused heterocycle;
• each instance of R5 is independently selected from the group consisting of
• —H,
• —C1-6 alkyl optionally substituted with one or more R6 groups,
• —C2-6 alkenyl optionally substituted with one or more R6 groups,
• —C0-3 alkyl-C3-6 cycloalkyl-C0-3 alkyl optionally substituted with one or more R6 groups,
• -phenyl optionally substituted with one or more R6 groups,
• —C═C-Ph optionally substituted with one or more R6 groups,
• and
• —C0-3 alkyl-heterocyclyl-C0-3 alkyl optionally substituted with one or more R6 groups, wherein the heterocyclyl group is a 5-, 6- or 7-membered aliphatic or aromatic optionally benzo-fused heterocycle;
• each instance of R6 is independently selected from the group consisting of -halo, —CN, —C1-6 alkyl, —OH, —C1-6 alkoxy, —C1-6 alkyl-NH2, —NHm[(CH2)nNH2]2-m, —NH2, —NH—C1-6 alkyl, and —N—C1-6dialkyl;
• n and m are integers, wherein each instance of n is independently chosen from 2 or 3, and each instance of m is independently chosen from 0 or 1.