Sulfonylureas and related compounds and use of same
AssigneesThe Provost, Fellows, Foundation Scholars, and the Other Members of Board, of the College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin, The University of Queensland
InventorsLuke O'Neill, Rebecca Coll, Matthew Cooper, Avril Robertson, Kate Schroder
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Abstract
The present invention provides for certain sulfonyl ureas and related compounds which have advantageous properties and show useful activity in the inhibition of activation of the NLRP3 inflammasome. Such compounds are useful in the treatment of a wide range of disorders in which the inflammation process, or more specifically the NLRP3 inflammasome, have been implicated as being a key factor.
Claims43
A compound of formula (I), or a pharmaceutically acceptable salt, solvate or prodrug thereof:
- wherein W is selected from O, S and Se;
- J is selected from S and Se;
- R1 is selected from the group consisting of 5-membered and 6-membered heterocyclyl, all of which may be optionally substituted;
- R2 is selected from a 2,6-dialkylphenyl, a 2,6-dialkyl-4-halophenyl, a 2,6-dicycloalkylphenyl, a 2,6-dicycloalkyl-4-halophenyl, and:
- wherein each incidence of Y is independently selected from C, N, S and O, which may be optionally substituted;
- R5 is selected from the group consisting of hydrogen, halo, cyano, amide, sulphonamide, acyl, hydroxyl, C1-C6 alkyl, C1-C6 haloalkyl, C3-C5 cyloalkyl and C1-C6 alkoxy, all of which groups may be optionally substituted with halo, cyano or C1-C6 alkoxy, and
- both R1 is directly bonded to J and R2 is directly bonded to the adjacent nitrogen, via a carbon atom.
Dependencies are inferred from the claim text.