VLP-based bivalent Ebola vaccines and methods of making and using same
AssigneeChildren's Hospital Medical Center
InventorsKarnail Singh, Paul Spearman
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Abstract
Disclosed herein are virus-like particle (VLP)-based bivalent vaccine compositions. The compositions may comprise a spherical retroviral Group—specific Antigen (“Gag”) protein core and at least two Ebola glycoproteins. The at least two Ebola glycoproteins may be located at the exterior surface of the spherical Gag protein core, such that the VLP-based vaccine presents at least two Ebola glycoprotein antigens. In one aspect, the at least two Ebola glycoproteins are a Zaire (EBOV) glycoprotein, and a Sudan (SUDV) glycoprotein.
Claims10
A virus-like particle (VLP)-based bivalent vaccine composition comprising a spherical retroviral Group-specific Antigen (“Gag”) protein core and at least two Ebola glycoproteins, wherein said at least two Ebola glycoproteins are incorporated into a surface of said spherical retroviral Gag protein core, wherein said VLP-based bivalent vaccine composition presents at least two Ebola glycoprotein antigens, wherein said spherical retroviral Gag protein core has a diameter of from about 100 to about 300 nanometers.
Dependencies are inferred from the claim text.