Retroviral particle comprising at least two encapsidated nonviral RNAs
AssigneeFlash Therapeutics
InventorsPascale Bouille, Jean-Christophe Pages, Régis Gayon
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Abstract
The present invention relates to a retroviral system for the transfer of non-viral RNA into target cells and more particularly a retroviral particle capable of delivering multiple RNAs. More particularly, it relates to retroviral particles comprising a protein derived from the Gag polyprotein an envelope protein, optionally an integrase and at least two encapsidated non-viral RNAs, the encapsidated non-viral RNAs each comprising an RNA sequence of interest linked to an encapsidation sequence, each encapsidation sequence being recognised by a binding domain introduced into the protein derived from the Gag polyprotein and/or into the integrase.
Claims6
A retroviral particle comprising a protein from a Gag polyprotein, an envelope protein, optionally an integrase, and at least two encapsidated, different, non-viral RNAs, the at least two encapsidated, different, non-viral RNAs each comprising an RNA sequence of interest linked to an encapsidation sequence, each encapsidation sequence bound to a heterologous binding domain introduced into the protein from the Gag polyprotein.
Dependencies are inferred from the claim text.