Back to results
US 11,124,542 B2Granted
Modulators of melanocortin receptors
AssigneeArizona Board of Regents on Behalf of the University of Arizona
InventorsVictor J. Hruby, Minying Cai
Life of this patent
Estimating the term…
Abstract
Modulators of melanocortin receptors (MCR) are provided herein. An MC5R peptide ligand is represented by to Formula 1: R1-Nle4-c[Xaa5-Yaa6-(NMe)D-Nal(2′)7-Arg8-Trp9-(NMe)Zaa10]-R2. R1 can be an acetyl, a glycosylated amino acid, —CO—(CH2)nCH3, or —CO—(CH2)nCF3 with n ranging from 1 to 6. R2 can be an —CONH2, —COOH, or —CH2OH. Xaa, Yaa, and Zaa can each be a natural amino acid or an unnatural amino acid.
Claims4
A melanocortin 5 receptor (MC5R) peptide ligand according to the formula:
- R1-Nle4-c[Asp5-Pro6-(NMe)D-Nal(2′)7-Arg8-Trp9-(NMe)Lys10]-R2,
- wherein R1 is an acetyl, a glycosylated amino acid, or —CO—(CH2)nCH3, wherein n ranges from 1 to 6, wherein R2 is an —CONH2, —COOH, or —CH2OH, and wherein the MC5R peptide ligand is an MC5R antagonist.
A melanocortin 5 receptor (MC5R) peptide ligand according to the formula:
- Ac-Nle4-c[Asp5-Pro6-(NMe)D-Nal(2′)7-Arg8-Trp9-(NMe)Lys10]-NH2,
- wherein the MC5R peptide ligand is an MC5R antagonist.
Dependencies are inferred from the claim text.