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US 11,124,472 B2Granted
Myocardial regeneration promoting compounds, preparation method thereof, and pharmaceutical composition
AssigneeGenhealth Pharma Co., Ltd.
InventorsLain-Tze Lee, Hui-Ping Tsai, Shu-Fen Huang, Yi-Wen Lin, Pi-Tsan Huang, Ying-Ying Wu, Mei-Hui Chen, Li-Jie Hsu
Life of this patent
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Abstract
The present invention discloses a novel 3-aryl-2-propen-1-one series derivative and the synthesis processes thereof. Besides, the present invention also discloses the series derivative as a pharmaceutical composition and their use for promoting myocardial regeneration.
Claims8
A compound represented by Formula (I) below:
- where X1 is a hydrogen atom or an unsubstituted alkyl group having 1 to 6 carbon atoms;
- X2 is an oxygen atom or an amino group;
- X3 is a hydrogen atom, a hydroxyl group, or *—X2—(CO)—(Y)p—Z group;
- Y is an alkylene group having 1 to 6 carbon atoms, an alkenylene group having 2 to 12 carbon atoms, an arylenealkylene group having 7 to 18 carbon atoms, or an arylene group having 6 to 18 carbon atoms;
- Z is *—COCH3, *—COOH, *—COOCH3, *—OCOCH3, *—NHCOOC(CH3)3, *—F, *—Cl, *—Br, or *—I;
- and
- p is 0 or 1,
- wherein, when X1 is a hydrogen atom, X3 is a hydrogen atom, and Y is an arylenealkylene group having 7 to 18 carbon atoms, Z is *—COOH, *—COOCH3, *—OCOCH3 or *—NHCOOC(CH3)3;
- wherein, when X1 is a hydrogen atom, X3 is a hydrogen atom, and Y is an arylene group having 6 to 18 carbon atoms, Z is *—COCH3, *—COOH, *—OCOCH3, or *—NHCOOC(CH3)3;
- or
- wherein, when X1 is a hydrogen atom, X3 is a hydrogen atom, and Y is an alkylene group having 1 to 6 carbon atoms or an alkenylene group having 2 to 12 carbon atoms, Z is *—COCH3, *—COOH, *—COOCH3, *—OCOCH3, *—NHCOOC(CH3)3, *—F, *—Cl, *—Br, or *—I,
- wherein, when X1 is an unsubstituted alkyl group having 1 to 6 carbon atoms and Y is an arylene group having 6 to 18 carbon atoms, Z is *—COCH3, *—COOH, *—COOCH3, *—NHCOOC(CH3)3, *—F, *—Cl, *—Br, or *—I, and
- wherein, when X1 is an unsubstituted alkyl group having 1 to 6 carbon atoms and Y is an alkylene group having 1 to 6 carbon atoms, an alkenylene group having 2 to 12 carbon atoms or an arylenealkylene group having 7 to 18 carbon atoms, Z is *—COCH3, *—COOH, *—COOCH3, *—OCOCH3, *—NHCOOC(CH3)3, *—F, *—Cl, *—Br, or *—I.
10 more elements
Dependencies are inferred from the claim text.