Compositions and methods for treating nonsteroidal anti-inflammatory drug (NSAID) associated coagulopathy, thrombocytopenia, glanzmann's thrombasthenia, and/or thrombosis
AssigneeYale University
InventorsDemetrios Braddock, Ronald Albright
Life of this patent
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Abstract
The present invention relates to compositions and methods for modulating coagulation through modulating the level or activity of ENPP4.
Claims24
A method of treating nonsteroidal anti-inflammatory drug (NSAID) associated coagulopathy in a mammal in need thereof, the method comprising administering to the mammal a therapeutically effective amount of an isolated soluble ectonucleotide pyrophosphatase/phosphodiesterase 4 (ENPP4) polypeptide comprising amino acid residues 1-407 of SEQ ID NO:1.
A method of treating thrombocytopenia in a mammal in need thereof, the method comprising administering to the mammal a therapeutically effective amount of an isolated soluble ectonucleotide pyrophosphatase/phosphodiesterase 4 (ENPP4) polypeptide comprising amino acid residues 1-407 of SEQ ID NO:1.
A method of treating Glanzmann's thrombasthenia in a mammal in need thereof, the method comprising administering to the mammal a therapeutically effective amount of an isolated soluble ectonucleotide pyrophosphatase/phosphodiesterase 4 (ENPP4) polypeptide comprising amino acid residues 1-407 of SEQ ID NO:1.
Dependencies are inferred from the claim text.