Auris formulations for treating otic diseases and conditions
AssigneesOtonomy, Inc., The Regents of the University of California
InventorsJay Lichter, Andrew M. Trammel, Fabrice Piu, Qiang Ye, Luis A. Dellamary, Carl Lebel, Jeffrey P. Harris
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Abstract
Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.
Claims21
A method of treating an otic disease or condition comprising administering to an individual in need thereof a therapeutically effective amount of a composition, wherein the composition comprises a multiparticulate gamma secretase inhibitor or pharmaceutically acceptable salt thereof, and about 15% to about 35% by weight of a polyoxyethylene-polyoxypropylene triblock copolymer, and wherein the multiparticulate gamma secretase inhibitor is not microencapsulated particles or nanoparticles.
Dependencies are inferred from the claim text.