Monitoring dissolution of a dosage form in progress during dissolution by low coherence interferometry
AssigneeResearch Center Pharmaceutical Engineering GmbH
InventorsMassimo Bresciani, Daniel Markl, Annalisa Mercuri, Johannes Khinast, Thomas Klein
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Abstract
A method of monitoring a property of a dissolution of an at least partially solid dosage form during a dissolution process is disclosed. The method includes at least partially dissolving the dosage form, and during the dissolution of the dosage form, simultaneously monitoring the property of the dissolution of the dosage form in progress by low coherence interferometry.
Claims18
A method of monitoring a property of a dissolution of an at least partially solid dosage form during a dissolution process, the method comprising:
- placing the at least partially solid dosage form in a dissolution apparatus comprising a flow through cell with an opening,
- at least partially dissolving the partially solid dosage form,
- supplying electromagnetic radiation from a sensor head of a monitoring apparatus to the at least partially solid dosage form in the dissolution apparatus with an electromagnetic radiation supply element that extends through the opening into the dissolution apparatus, such that the electromagnetic radiation is getting in contact with the partially solid dosage form to be monitored, and
- during the dissolution of the partially solid dosage form, simultaneously monitoring the property of the dissolution of the dosage form in progress by low coherence interferometry.
A device for dissolving a partially solid dosage form and monitoring a property of the dissolution of the partially solid dosage form during a dissolution process, the device comprising:
- a dissolution apparatus configured for at least partially dissolving the partially solid dosage form, wherein the dissolution apparatus comprises a flow through cell;
- a monitoring apparatus configured for monitoring the property of the dissolution of the partially solid dosage form during dissolving the partially solid dosage form by the dissolution apparatus,
- wherein the monitoring apparatus is configured for monitoring the property of the dissolution of the partially solid dosage form simultaneously with and during a dissolution process using low coherence interferometry;
- and
- an electromagnetic radiation supply element configured for supplying electromagnetic radiation from a sensor head of the monitoring apparatus to the partially solid dosage form in the dissolution apparatus, such that the electromagnetic radiation is getting in contact with the partially solid dosage form to be monitored;
- wherein the electromagnetic radiation supply element extends from the sensor head to the partially solid dosage form, and
- wherein the electromagnetic radiation supply element extends through an opening of the flow through cell into the dissolution apparatus.
Dependencies are inferred from the claim text.