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US 11,118,184 B2Granted
Asymmetric siRNA for inhibiting expression of male pattern hair loss target gene
AssigneeOliX Pharmaceuticals, Inc.
InventorsSun Woo Hong, Jihye Hwang
Life of this patent
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Abstract
The present invention relates to an asymmetric siRNA which inhibits an expression of male pattern hair loss target genes and a use thereof and, more particularly, to an asymmetric siRNA which inhibits an expression of 3-oxo-5-alpha-steroid-4-dehydrogenase 1 (SRD5A1) gene, 3-oxo-5-alpha-steroid-4-dehydrogenase 2 (SRD5A2) gene or androgen receptor (AR) gene, and a composition for prevention or treatment of hair loss comprising the asymmetric siRNA.
Claims6
The siRNA specifically binding to mRNA of an androgen receptor (AR)-encoding gene having SEQ ID NO:
- 673 and comprising a sense strand consisting of the sequence of SEQ ID NO:
- 500 and an antisense strand complementary to the sense strand and consisting of the sequence of SEQ ID NO:
- 618,
- wherein a 3′-terminus of the sense strand and a 5′-terminus of the antisense strand form a blunt end.
1 more element
Dependencies are inferred from the claim text.