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US 11,118,166 B2Granted
Production of viruses in avian eggs
AssigneesCommonwealth Scientific and Industrial Research Organisation, University of Georgia Research Foundation, Inc.
InventorsAndrew Bean, John William Lowenthal, Luis Fernando Malaver-Ortega, Ralph A. Tripp
Life of this patent
Estimating the term…
Abstract
The present invention relates to modified avian eggs which can be used to produce increased levels of virus. The present invention also relates to methods of producing viruses in avian eggs of the invention, as well as the use of the viruses obtained to prepare vaccine compositions.
Claims19
A method of replicating a virus, the method comprising;
- 1) inoculating an avian egg with a virus, wherein the avian egg comprises a genetic modification in the genome of the egg which knocks-out expression of the interferon alpha/beta receptor 1 (IFNAR1) gene in the egg, wherein the egg is capable of producing more virus than the isogenic egg lacking the genetic modification;
- and
- 2) incubating the egg for a predetermined period of time to replicate the virus.
Dependencies are inferred from the claim text.