Immunogenic compositions for the prevention and treatment of meningococcal disease
AssigneeWyeth Holdings Corporation
InventorsGary W. Zlotnick, Leah D. Fletcher, John E. Farley, Liesel A. Bernfield, Robert J. Zagursky, Benjamin J. Metcalf
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Abstract
The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that immunospecifically bind to the foregoing and nucleic acid sequences encoding each of the foregoing, as well as the use of same in immunogenic compositions that are effective against infection by Neisseria meningitidis serogroup B.
Claims14
A composition comprising an immunologically effective amount of a purified polypeptide comprising any of the amino acid sequences of SEQ ID NO:
- 92, SEQ ID NO:
- 94, and SEQ ID NO:
- 96 and an immunologically effective amount of at least one adjuvant.
Dependencies are inferred from the claim text.