Systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking

A normalization device configured to facilitate normalization of medical images of a coronary region of a subject for an algorithm-based medical imaging analysis, the normalization device comprising:

• a substrate having a width, a length, and a depth dimension, the substrate having a proximal surface and a distal surface, the proximal surface adapted to be placed adjacent to a surface of a body portion of the subject;
• a plurality of compartments positioned within the substrate, each of the plurality of compartments configured to hold a sample of a known material, wherein:
• a first subset of the plurality of compartments hold at least one sample of a contrast material, a second subset of the plurality of compartments hold samples of materials representative of materials to be analyzed by the algorithm-based medical imaging analysis, wherein a first compartment of the first subset of the plurality of compartments is positioned immediately adjacent to a second compartment of the second subset of the plurality of compartments such that a first sample held in the first compartment is juxtaposed with a second sample held in the second compartment
• wherein the samples of materials representative of materials to be analyzed comprise at least two samples of calcium having different radiodensities, and a third subset of the plurality of compartments hold at least one sample of a phantom material;
• and an attachment mechanism on the proximal surface of the substrate and configured to attach the normalization device to the body portion of the subject.