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US 11,112,410 B2Granted
Methods for capturing, isolation, and targeting of circulating tumor cells and diagnostic and therapeutic applications thereof
AssigneePresident and Fellows of Harvard College
InventorsJoo-Hun Kang, Donald E. Ingber, Michael Super, Alexander L. Watters, Harry Scott Driscoll
Life of this patent
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Abstract
The invention relates to methods of detection, capture, isolation and targeting of cancer cells for example circulating tumor cells (CTCs) using carbohydrate recognition domain of a lectin. The invention relates to methods of diagnosis, prognosis and treatment of cancer.
Claims19
A method for capturing circulating tumor cells (CTCs) from a biological fluid of a subject, comprising;
- contacting the biological fluid with a C-type lectin molecule comprising a carbohydrate recognition domain (CRD) of mannose binding lectin attached to a surface.
A method for generating cancer vaccine, comprising:
- (a) contacting a sample containing CTCs from a cancer patient with C-type lectin molecule comprising a carbohydrate recognition domain (CRD) of mannose binding lectin attached to a surface, whereby the lectin molecule binds the CTCs in the sample, thereby providing captured CTCs;
- (b) isolating the captured CTCs;
- (c) combining the isolated CTCs or a component thereof with an adjuvant to generate a CTC-immunogen thereby producing a cancer vaccine.
Dependencies are inferred from the claim text.